Beckervordersandforth Lab
Astrocyte Diversity and Dynamics
Publications
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Publications
Schneider, Y., Gauer, C., Andert, M., Hoffmann, A., Riemenschneider, M. J., Krebs, W., ... & Winkler, J. (2024). Distinct forebrain regions define a dichotomous astrocytic profile in multiple system atrophy. Acta Neuropathologica Communications, 12(1), 1. doi: 10.1186/s40478-023-01699-3
Chalmers, N., Masouti, E., & Beckervordersandforth, R. (2024). Astrocytes in the adult dentate gyrus—balance between adult and developmental tasks. Molecular Psychiatry, 1-10. doi: 10.1038/s41380-023-02386-4
Sommer, J., Ehnis, H., Seitz, T., Schneider, J., Wild, A. B., Moceri, S., ... & Hellerbrand, C. (2023). Four-and-a-Half LIM-Domain Protein 2 (FHL2) Induces Neuropeptide Y (NPY) in Macrophages in Visceral Adipose Tissue and Promotes Diet-Induced Obesity. International Journal of Molecular Sciences, 24(19), 14943. doi: 10.3390/ijms241914943
Stüfchen, I., Beyer, F., Staebler, S., Fischer, S., Kappelmann, M., Beckervordersandforth, R., & Bosserhoff, A. K. (2023). Sox9 regulates melanocytic fate decision of adult hair follicle stem cells. Iscience, 26(6). doi: 10.1016/j.isci.2023.106919
Stüfchen, I., Beckervordersandforth, R., Fischer, S., Kappelmann‐Fenzl, M., Bosserhoff, A. K., & Beyer, F. (2022). Two novel CreERT2 transgenic mouse lines to study melanocytic cells in vivo. Pigment Cell & Melanoma Research, 35(6), 613-621. doi: 10.1111/pcmr.13061
Karpf, J., Unichenko, P., Chalmers, N., Beyer, F., Wittmann, M. T., Schneider, J., ... & Beckervordersandforth, R. (2022). Dentate gyrus astrocytes exhibit layer-specific molecular, morphological and physiological features. Nature Neuroscience, 1-13. doi: 10.1038/s41593-022-01192-5
Schneider, J., Weigel, J., Wittmann, M. T., Svehla, P., Ehrt, S., Zheng, F., ... & Beckervordersandforth, R. (2022). Astrogenesis in the murine dentate gyrus is a life‐long and dynamic process. The EMBO Journal, e110409. doi: 10.15252/embj.2021110409
Beyer F, Lüdje W, Karpf J, Saher G, Beckervordersandforth R (2021) Distribution of Aldh1L1-CreERT2 recombination in astrocytes versus neural stem cells in the neurogenic niches of the adult mouse brain. Front. Neurosci. 15:713077.
doi: 10.3389/fnins.2021.713077
Fiebig C, Keiner S, Ebert B, Schäffner I, Jagasia R, Lie DC, Beckervordersandforth R (2019) Mitochondrial dysfunction in astrocytes impairs the generation of reactive astrocytes and enhances neuronal cell death in the cortex upon photothrombotic lesion. Front. Molecular Neurosci 12:40. doi: 10.3389/fnmol.2019.00040
Schäffner I, Minakaki G, Khan MA, Balta EA, Schlötzer-Schrehardt U, Schwarz T, Beckervordersandforth R, Winner B, Webb AE, DePinho R, Paik J, Wurst W, Klucken J, and Lie DC (2018) FoxO function is essential for maintenance of autophagic flux and neuronal morphogenesis in adult neurogenesis. Neuron 2018 Sep 19;99(6):1188-1203. doi: 10.1016/j.neuron.2018.08.017
Pons-Espinal M, de Luca E, Marzi MJ, Beckervordersandforth R, Armirotti A, Nicassio F, Fabel K, Kempermann G, De Pietri Tonelli D (2017) Synergistic functions of miRNAs determine neuronal fate of adult neural stem cells. Stem Cell Reports, 2017 April 11; 8(4):1046-1061. doi: 10.1016/j.stemcr.2017.02.012
Beckervordersandforth R#*, Ebert B*, Shin J, Fiebig C, Moss J, Moore DL, Ghosh L, Trinchero MF, Stockburger C, Friedland K, Steib K, Schäffner I, von Wittgenstein J, Keiner S, Redecker C, Hölter SM, Wurst W, Jagasia R, Schinder AF, Jessberger S, Ming GL, Song H, Toni N, Lie DC# (2017) Role of mitochondrial metabolism in the control of early lineage progression and aging phenotypes in adult hippocampal neurogenesis. Neuron 2017 Feb 8 93: 1-14. doi: 10.1016/j.neuron.2016.12.017
# Corresponding authors
* Equal contribution
Gebara E, Bonaguidi MA*, Beckervordersandforth R*, Sultan S, Udry F, Gijs PJ, Lie DC, Ming G, Song S, and Toni N. (2015) Heterogeneity of radial glia-like cells in the adult hippocampus. Stem Cells 2016 Jan 1. doi: 10.1002/stem.2266
* Equal contribution
Fukusumi Y, Meier M, Götz S, Matheus F, Irmler M, Beckervordersandforth R, Faus-Kessler T, Minina E, Rauser B, Zhang J, Arenas E, Andersson E, Niehrs C, Beckers J, Simeone A, Wurst W, and Prakash N. (2015) Dickkopf 3 promotes the differentiation of a rostrolateral midbrain dopaminergic neural subset in vivo and from pluripotent stem cells in vitro in mouse. J Neurosci. 2015 September 30;35(39):13385-13401.
Lead experimentalist for FACS analysis
Karow M, Schichor C, Beckervordersandforth R, and Berninger B. (2014) Lineage-reprogramming of pericyte-derived cells of the adult human brain into induced neurons. Journal of visualized experiments JoVE 01/2014.
doi: 10.3791/51433
Lead experimentalist for FACS analysis
Beckervordersandforth, R#, Deshpande A, Schäffner I, Huttner HB, Lepier A, Lie CD, and Götz, M. (2014) In vivo targeting of adult neural stem cells in the dentate gyrus by a split-Cre approach. Stem Cell Reports, 2014 Feb 6; 2(2);153-162.
doi: 10.1016/j.stemcr.2014.01.004
# Corresponding author
Fischer J*, Beckervordersandforth R*, Tripathi P, Steiner-Mezzadri A, Ninkovic J, and Götz, M. (2011) Prospective isolation of the adult neural stem cells and their progeny from the mouse subependymal zone. Nat Protoc. 2011 Nov 17 ;6(12) :1981-9.
* Equal contribution
Costa MR, Ortega F, Brill MS, Beckervordersandforth R, Petrone C, Schroeder T, Götz M, and Berninger B. (2012) Continuous live imaging of adult neural stem cell division and lineage progression in vitro. Development, 138 (2011), 1057-1068 (2011). doi.org/10.1242/jcs.088575
Eilken H, Rieger MA, Hoppe PS, Hermann AC, Smejkal BM, Drew EC, Thum M, Ninkovic J, Beckervordersandforth R, and Schroeder T. (2011) Continuous long-term detection of live cell surface markers by 'in culture' antibody staining. Nature Protocol Exchange 2011 Jan (28); doi:10.1038/protex.2011.205
Beckervordersandforth R*, Tripathi P*, Ninkovic J*, Bayam E, Lepier A, Stempfhuber B, Kirchhoff F, Hirrlinger J, Haslinger A, Lie DC, Beckers J, Yoder B, Irmler M, and Götz M. (2010) In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells. Cell Stem Cell. 2010 Dec 3;7(6):744-58. doi: 10.1016/j.stem.2010.11.017
* Equal contribution
Gajera CR, Emich H, Lioubinski O, Christ A, Beckervordersandforth-Bonk R, Yoshikawa K, Bachmann S, Christensen EI, Götz M, Kempermann G, Perterson AS, Willnow TE, and Hammes A. (2010) LRP2 in ependymal cells regulates BMP signalling in the adult neurogenic niche. J Cell Sci. 2010 Jun 1;123(Pt11):1922-30. Epub 2010 May11.
Beckervordersandforth RM, Rickert C, Altenhein B, and Technau GM. (2008) Subtypes of glial cells in the Drosophila embryonic ventral nerve cord as related to lineage and gene expression. Mech Dev. 2008 May-Jun;125(5-6):542-57. Epub 2008 Jan 8. doi: 10.1016/j.mod.2007.12.004
von Hilchen CM, Beckervordersandforth RM, Rickert C, Technau GM, and Altenhein B. (2008) Identity, origin, and migration of peripheral glial cells in the Drosophila embryo. Mech Dev. 2008 Mar-Apr;125(3-4):337-52. Epub 2007 Nov 1. doi: 10.1016/j.mod.2007.10.010
BOOK CHAPTERS
Schneider J, Karpf J, Beckervordersandforth R# (2019) Role of Astrocytes in the neurogenic niches. Methods in Molecular Biology, vol. 1938 (2019).
doi: 10.1007/978-1-4939-9068-9_2
Beckervordersandforth R, Zhang CL, and Lie DC. 2015
Transcription factor-dependent control of adult hippocampal neurogenesis
Cold Spring Harb Perspecti. Biol doi: 10.1101/cshperspect.a018879.
doi: 10.1101/cshperspect.a018879
REVIEW/PREVIEW
Beckervordersandforth R and Rolando C (2020) Untangling human neurogenesis to understand and counteract brain disorders. Current Opinion in Pharmacology 2020. 50:67-73. doi: 10.1016/j.coph.2019.12.002
Beckervordersandforth R (2017) Newborn neurons in the aged brain - scarce and slow but highly plastic. Cell Reports 21, October 31, 2017. doi: 10.1016/j.celrep.2017.10.049
Beckervordersandforth R (2017) Mitochondrial metabolism-mediated regulation of adult neurogenesis. Brain Plasticity 3 (2017) 73-87. doi: 10.3233/BPL-170044
Beckervordersandforth R, Häberle BM, and Lie DC. (2015) Metabolic regulation of adult stem cell-derived neurons. Front.Biol., 2015, 10(2):107-116. doi: 10.1007/s11515-015-1351-5
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